What is Homology?
Protein homology shows how closely different organisms are related based on their protein sequences. Homologous traits can indicate descent from a common ancestor. The protein homologs for SMPD1 were found using Homologene. The maximum identity values are included below to show how similar the organisms' sequence is to humans with a higher percentage denoting a higher relatedness. BLASTs were run in order to determine these maximum identity values, and the amount of error value was included below as well from these results.
Homologous Proteins - SMPD1
Homo Sapiens - Humans
Protein Name: SMPD isoform 1 Accession Number: NP_000534.3 FASTA Pan troglodytes - Chimpanzee Protein Name: SMPD isoform 3 Accession Number: XP_508253.2 FASTA E-Value: 0.0 Max. Identity: 98% Macaca mulatta - Rhesus Monkey Protein Name: SMPD isoform 4 precursor Accession Number: XP_001110212.1 FASTA E-Value: 0.0 Max. Identity: 97% Canis lupus familiaris - Dog Protein Name: SMPD isoform 1 Accession Number: XP_542452.1 FASTA E-Value: 0.0 Max. Identity: 85% Bos taurus - Cow Protein Name: SMPD precursor Accession Number: NP_001068655.1 FASTA E-Value: 0.0 Max. Identity: 85% Homologene Results |
Mus musculus - Mouse
Protein Name: SMPD1 acid lysosomal Accession Number: NP_035551.1 FASTA E-Value: 0.0 Max. Identity: 82% Gallus gallus- Chicken Protein Name: SMPD-like (partial) Accession Number: XP_003640663.1 FASTA E-Value: 0.0 Max. Identity: 66% Danio rerio - Zebrafish Protein Name: SMPD isoform 1 Accession Number: XP_683907.1 FASTA E-Value: 0.0 Max. Identity: 59% Drosophila melanogaster - Fruit Fly Protein Name: CG3376 isoform B Accession Number: NP_611904.1 FASTA E-Value: 4e-146 Max. Identity: 42% Caenorhabditis elegans - Worm Protein Name: Protein ASM-2 Accession Number: NP_509894.2 FASTA E-Value: 9e-123 Max. Identity: 35% |
Analysis and Discussion
In humans the protein name is SMPD1, but the protein homologs in other organisms sometimes have different names. There are different isoforms of SMPD with SMPD2 and SMPD3 being the next most common after SMPD1. These isoforms have both lost catalytic activity. C. elegans and Drosophila have the most unique name for their proteins. The vertebrates are more closely related to the protein sequence in humans than the invertebrates. For instance, chimpanzees have a maximum identity value of 98%, whereas C. elegans only have a maximum identity of 35%. In the case of model organisms, this means the mouse would be the best model organism to study this protein in. Other model organisms, such as Zebrafish, Drosophila, and C. elegans have less than 60% similarity. It would not be as beneficial to study them because they are lacking important information.